Hydroxamide derivatives of short-chain fatty acid have erythropoietic activity and induce γ gene expression in vivo

Hydroxamic acid derivatives can stimulate the in vivo erythropoiesis and fetal globin production in a thalassemic murine model. The combined effect of certain histone deacetylase inhibitors on erythropoiesis and on γ gene expression make these compounds desirable targets for development of therapeutics for β chain hemoglobinopathies.