Comparative gene expression profiling of cytokine-induced killer cells in response to acute myloid leukemic and acute lymphoblastic leukemic stimulators using oligonucleotide arrays

In addition to demonstrating the presence of molecular regulatory pathways that are common to CIK effector cells, our present study also reveals molecular events that are unique to CIK effectors on stimulation with cytolytic-susceptible (AML) or cytolytic-resistant (ALL) targets. These observations could allow the design of strategies for future research on the application of CIK effector cells for cancer immunotherapy.