STI 571 inhibition effect on KITAsn822Lys-mediated signal transduction cascade

These findings show the role of PI3K in KITAsn822Lys-mediated constitutive activation through the Akt-independent downstream signaling pathway of JNK, and also demonstrate the mutant's susceptibility to STI 571, which may therefore have therapeutic potential in CBFL patients with susceptible KIT mutations.