TGF-β1 inhibits late-stage mast cell maturation

TGF-β1 may contribute to mast cell homeostasis by inhibiting maturation from bone marrow precursors. The effects of TGF-β1 result in greatly diminished expression of cell surface markers, reduced granulation, and lack of responsiveness to IgE-mediated activation. Thus TGF-β1 can serve as a potent and multifunctional regulator of mast cell maturation.