Oncogenic Ras blocks transforming growth factor-β-induced cell-cycle arrest by degradation of p27 through a MEK/Erk/SKP2-dependent pathway

N-RasL61 transformed cells lack a G0-G1 arrest upon TGF-β treatment due to absence of p27. p27 is degraded through a MapK-, and SKP2-dependent pathway. Overexpression of p27 results in restoration of cell-cycle arrest upon TGF-β treatment.