کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10908969 1087819 2012 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Retreatment with purine analogs in patients with chronic lymphocytic leukemia
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Retreatment with purine analogs in patients with chronic lymphocytic leukemia
چکیده انگلیسی
We evaluated the efficacy and toxicity of retreatment with purine analogs (PA) in 62 patients with relapsed chronic lymphocytic leukemia. Median OS and PFS after retreatment were 60 and 26 months, respectively. By multivariate analysis, minimal residual disease status, ZAP-70 expression and age had independent predictive power in terms of OS. Toxicity was mainly neutropenia (21%) and infections (39%). Second malignancies were observed in 10 (16%) patients. Our results outline that retreatment with PA is remarkably effective in patients with relapsed CLL, but with a significant toxicity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Leukemia Research - Volume 36, Issue 12, December 2012, Pages 1521-1525
نویسندگان
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