کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10909029 1087822 2014 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Identification of B-cell lymphoma subsets by plasma protein profiling using recombinant antibody microarrays
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Identification of B-cell lymphoma subsets by plasma protein profiling using recombinant antibody microarrays
چکیده انگلیسی
B-cell lymphoma (BCL) heterogeneity represents a key issue, often making the classification and clinical management of these patients challenging. In this pilot study, we outlined the first resolved view of BCL disease heterogeneity on the protein level by deciphering disease-associated plasma biomarkers, specific for chronic lymphocytic leukemia, diffuse large B-cell lymphoma, follicular lymphoma, and mantle cell lymphoma, using recombinant antibody microarrays targeting mainly immunoregulatory proteins. The results showed the BCLs to be heterogeneous, and revealed potential novel subgroups of each BCL. In the case of diffuse large B-cell lymphoma, we also indicated a link between the novel subgroups and survival.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Leukemia Research - Volume 38, Issue 6, June 2014, Pages 682-690
نویسندگان
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