کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10909337 | 1087853 | 2009 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Impact of transfusion dependency on survival in patients with early myelodysplastic syndrome without excess of blasts
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کلمات کلیدی
ISCNAMLRCMDWPSSPNHIPSSMDSRBCLFSRARs - RAR هاMRI - امآرآی یا تصویرسازی تشدید مغناطیسیLeft ventricular - بطن چپSurvival - بقاoverall survival - بقای کلTransfusion - ترانسفوزیون یا انتقال خونMagnetic resonance imaging - تصویربرداری رزونانس مغناطیسیintermediate - حد واسطWorld Health Organization - سازمان بهداشت جهانیmyelodysplastic syndrome - سندرم میلودیسپلاستیکRefractory cytopenia with multilineage dysplasia - سیتوپنی مقاوم به درمان با دیسپلازی چند لاینInternational Prognostic Scoring System - سیستم امتیاز دهی بین المللی بین المللیFab - فابFrench–American–British - فرانسوی-آمریکایی-انگلیسیacute myeloid leukemia - لوسمی حاد میلوئیدی یا به اختصار AMLMyelodysplasia - میلولد پلاسسیاIron overload - هموکروماتوزparoxysmal nocturnal hemoglobinuria - هموگلوبینوری شب ادراری پراکسیاسمیprognosis - پیش شناخت بیماریejection fraction - کسری خروجیlow - کمRefractory anemia - کم خونی مقاومrefractory anemia with ringed sideroblasts - کم خونی مقاوم به درمان با سیتوبلاست های حلقویWHO - کهred blood cell - گلبول قرمز، اریتروسیت
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Impact of transfusion dependency on survival in patients with early myelodysplastic syndrome without excess of blasts Impact of transfusion dependency on survival in patients with early myelodysplastic syndrome without excess of blasts](/preview/png/10909337.png)
چکیده انگلیسی
We present a retrospective analysis of 137 patients with early MDS without excess of blasts that revealed transfusion dependency in 87% of the cases. A significant difference in overall survival was noted between patients receiving â¤2 units and those receiving >2 units of RBC transfusions/month (65.0 vs. 35.3 months, respectively, P = 0.02). Univariate statistical analysis identified the presence of disease progression to advanced MDS (Ï2 = 26.4, P = 0.001) and the administration of >1 or >2 units of RBC per month (Ï2 = 15.9 and 14.6, respectively, P = 0.001) as the most important parameters affecting survival. Nevertheless, even the administration of 1 RBC unit every 4-8 weeks had a significantly adverse impact on survival compared to non-transfused patients. Transfusion dependency itself did not affect disease progression as determined by the presence of multilineage dysplasia and adverse karyotype (expressed by the IM-1 or IM-2 score). Multivariate analysis confirmed disease progression towards leukemia as a highly significant independent variable affecting survival (P = 0.0001). None of the other evaluated parameters had a significant impact on survival in patients with progressive disease. In non-transplanted patients without MDS progression, administration of >2 units of RBC transfusions/month was the only independent variable with adverse impact on survival in patients with unilineage erythroid dysplasia (P = 0.02). In patients with multilineage dysplasia, only heavy transfusion dependency (>3 TU RBC/month) and serum ferritin >2000 μg/l adversely affected survival (P = 0.03). Modification of the WPSS by replacing transfusion dependency with initial Hb level <80 g/l retained its prognostic relevance and allowed the identification of a potential risk subset of early MDS patients with intermediate and high scores and limited survival (<40% at 5 years) as early as at the time of diagnosis. Our results confirm a significant negative impact of transfusion dependency on survival in patients with early MDS without excess of blasts. The main risk subgroup is characterized by unilineage dysplasia limited to erythropoiesis in combination with dependency on >2 TU of RBC per month. These patients usually have prolonged survival that leads to the development of heavy transfusion iron overload and they thus represent the most important target group for intensive chelation therapy.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Leukemia Research - Volume 33, Issue 11, November 2009, Pages 1469-1474
Journal: Leukemia Research - Volume 33, Issue 11, November 2009, Pages 1469-1474
نویسندگان
Jaroslav Cermak, Petra Kacirkova, Dana Mikulenkova, Kyra Michalova,