کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10909383 | 1087855 | 2011 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Expression of liquoral neuroprotection markers in children with acute lymphoblastic leukemia
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Expression of liquoral neuroprotection markers in children with acute lymphoblastic leukemia Expression of liquoral neuroprotection markers in children with acute lymphoblastic leukemia](/preview/png/10909383.png)
چکیده انگلیسی
Brain damage related to intrathecal methotrexate in children with acute lymphoblastic leukemia (ALL) is still unclear. Neuroinflammatory mechanisms and intracerebral production of specific biomarkers, play a key role in determining neuroprotective mechanisms after brain injury. To determine whether the CSF concentrations of neuron-specific enolase (NSE), neurotrophic factors and doublecortin (DCX) are influenced by repeated intrathecal methotrexate administrations, we prospectively collected CSF samples from 10 children with ALL and 10 controls. Our results showed an increased expression of the liquoral markers. This up-regulation could be interpreted as a neuroprotective response of the brain against the neuronal damages induced by MTX.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Leukemia Research - Volume 35, Issue 11, November 2011, Pages 1467-1471
Journal: Leukemia Research - Volume 35, Issue 11, November 2011, Pages 1467-1471
نویسندگان
Antonio Chiaretti, Antonio Ruggiero, Paola Coccia, Alessia Antonelli, Filomena Pierri, Giovanni Barone, Giorgio Attinà , Laura Iuvone, Palma Maurizi, Riccardo Riccardi,