کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10909511 1087905 2005 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Glycosylated or non-glycosylated G-CSF differently influence human granulocyte functions through RhoA
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Glycosylated or non-glycosylated G-CSF differently influence human granulocyte functions through RhoA
چکیده انگلیسی
In this paper we show that in resting Filgrastim (non-glycosylated G-CSF)-pulsed cells, F-actin polymerization, membrane-linked RhoA and cell polarization are enhanced compared to those found in resting Lenograstim (glycosylated G-CSF)-cells. The basal hyper-activation of RhoA could be responsible for the morphological and functional modifications of Filgrastim-mobilized cells. Moreover, Filgrastim-mobilized cells, but not Lenograstim-mobilized cells, are unable to correctly respond to LPS stimulation, as demonstrated by minor further RhoA activation and cell elongation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Leukemia Research - Volume 29, Issue 11, November 2005, Pages 1285-1292
نویسندگان
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