کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10909532 1087910 2005 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Lovastatin alters the isoprenoid biosynthetic pathway in acute myelogenous leukemia cells in vivo
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Lovastatin alters the isoprenoid biosynthetic pathway in acute myelogenous leukemia cells in vivo
چکیده انگلیسی
Lovastatin, a competitive inhibitor of hydroxymethylglutaryl coenzyme A reductase (HMGR), is used therapeutically to lower plasma cholesterol levels and has garnered attention for its cytotoxic effects in leukemia cells. In this study, escalating doses of lovastatin were administered to nine patients with acute myelogenous leukemia. Peripheral blood leukemia cells were drawn pre- and post-lovastatin dosing. Plasma lovastatin bioactivity ranged up to 234 nM lovastatin equivalents. Our results show that in vivo lovastatin, at up to 200 mg/dose, induces an increased activity of leukemia cell HMGR and alters leukemia cell proliferation without discernibly altering Ras processing.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Leukemia Research - Volume 29, Issue 5, May 2005, Pages 527-533
نویسندگان
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