کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10909787 1087938 2005 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Development of two cytogenetically abnormal clones from multipotential hematopoietic stem cells in a patient with juvenile myelomonocytic leukemia
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Development of two cytogenetically abnormal clones from multipotential hematopoietic stem cells in a patient with juvenile myelomonocytic leukemia
چکیده انگلیسی
We report a patient with juvenile myelomonocytic leukemia who had two cytogenetically independent clones at the time of diagnosis. Fluorescence in situ hybridization analyses showed that 42.5% of myeloperoxidase+ cells and 27.3% of CD20+ cells had three signals for chromosome 8, while 13.1% of myeloperoxidase+ cells and 6.0% of CD20+ cells had del (Y). However, a great majority of CD3+ cells had no numerical aberration of the two chromosomes. The two karyotypically abnormal clones might have developed from multipotential hematopoietic stem cells with the potential to differentiate into myeloid and B-lymphoid lineages, but not T-lymphoid lineage.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Leukemia Research - Volume 29, Issue 9, September 2005, Pages 1069-1072
نویسندگان
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