کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10909787 | 1087938 | 2005 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Development of two cytogenetically abnormal clones from multipotential hematopoietic stem cells in a patient with juvenile myelomonocytic leukemia
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موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
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چکیده انگلیسی
We report a patient with juvenile myelomonocytic leukemia who had two cytogenetically independent clones at the time of diagnosis. Fluorescence in situ hybridization analyses showed that 42.5% of myeloperoxidase+ cells and 27.3% of CD20+ cells had three signals for chromosome 8, while 13.1% of myeloperoxidase+ cells and 6.0% of CD20+ cells had del (Y). However, a great majority of CD3+ cells had no numerical aberration of the two chromosomes. The two karyotypically abnormal clones might have developed from multipotential hematopoietic stem cells with the potential to differentiate into myeloid and B-lymphoid lineages, but not T-lymphoid lineage.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Leukemia Research - Volume 29, Issue 9, September 2005, Pages 1069-1072
Journal: Leukemia Research - Volume 29, Issue 9, September 2005, Pages 1069-1072
نویسندگان
Satoshi Matsuzaki, Kazuyuki Matsuda, Jun Miki, Yozo Nakazawa, Kazuo Sakashita, Takehiko Kamijo, Eiko Hidaka, Kenichi Koike,