کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10912385 | 1088420 | 2005 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Sialyl Lewis antigens: association with MUC5AC protein and correlation with post-operative recurrence of non-small cell lung cancer
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
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چکیده انگلیسی
Sialyl Lewis antigens (sLex/a) are cancer-associated carbohydrate determinants, serve as ligands of the selectin family and are associated with hematogenous metastasis of cancer. So far, the clinicopathologic values of sialyl Lewis x (sLex) and sialyl Lewis a (sLea) in lung cancer have remained controversial. Using immunohistochemistry, the expressions of sLex and sLea antigens, and an airway mucin (MUC5AC) protein, which was supposed to be the major carrying protein of sialyl Lewis moieties, were studied in surgically resected tumor tissues of 61 patients with stages I or II NSCLC. Thirty-two (52.5%) of the 61 studied subjects were found to be positive for expression of sLea, 40 (65.6%) were positive for expression of sLex, and 16 (26.2%) were positive for MUC5AC protein. Both the expression of sLex and MUC5AC were associated with adenocarcinoma subtype. Patients bearing tumors with MUC5AC and/or sLex expression had a higher probability of post-operative distant metastasis. Survival analysis demonstrated that patients bearing tumors with expression of sLex antigen or MUC5AC had shorter overall survival. The multivariate logistic regression showed that age >65 years old (OR = 0.207, 95% CI = 0.075-0.569, P = 0.002), nodal status (OR = 6.575, 95% CI = 2.459-17.583, P < 0.001), and MUC5AC (OR = 5.545, 95% CI = 1.998-15.386, P = 0.001) were independent factors affecting survival. We concluded that the expression of sLex was related to MUC5AC protein, while patients with tumors co-expressing both MUC5AC and sLex antigen had the worst survival.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Lung Cancer - Volume 47, Issue 1, January 2005, Pages 59-67
Journal: Lung Cancer - Volume 47, Issue 1, January 2005, Pages 59-67
نویسندگان
Chong-Jen Yu, Jin-Yuan Shih, Yung-Chie Lee, Chia-Tong Shun, Ang Yuan, Pan-Chyr Yang,