Identification of a functional proprotein convertase cleavage site in microfibril-associated glycoprotein 2

► MAGP2 can exist extracellularly in a cleaved or uncleaved state. ► MAGP2 cleavage is mediated by proprotein convertases. ► The MAGP2 proprotein convertase consensus site is highly conserved. ► MAGP2 secretion is independent of cleavage.