کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10914633 | 1088803 | 2014 | 18 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
14-3-3 and β-catenin are secreted on extracellular vesicles to activate the oncogenic Wnt pathway
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: 14-3-3 and β-catenin are secreted on extracellular vesicles to activate the oncogenic Wnt pathway 14-3-3 and β-catenin are secreted on extracellular vesicles to activate the oncogenic Wnt pathway](/preview/png/10914633.png)
چکیده انگلیسی
Aberrant activation of the canonical Wnt signal transduction pathway is involved in a large number of human diseases. β-catenin, the key effector protein of the canonical Wnt pathway, functions in the nucleus with T-cell factor/lymphoid enhancer factor (TCF/LEF) to activate expression of Wnt target genes. Here we show that members of the 14-3-3 protein family bind disheveled-2 (Dvl-2) and glycogen synthase-3β (GSK-3β) to attenuate the interaction between GSK-3β and β-catenin. Importantly, 14-3-3 and β-catenin form “bleb-like” structures and are secreted via extracellular vesicles to induce Wnt signaling activity in target cells. Our data suggest a novel way of transducing the oncogenic Wnt signal in which β-catenin is regulated by 14-3-3ζ through the formation of “oncosomes” that contain both the 14-3-3 and β-catenin proteins.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular Oncology - Volume 8, Issue 5, July 2014, Pages 894-911
Journal: Molecular Oncology - Volume 8, Issue 5, July 2014, Pages 894-911
نویسندگان
Shiri Dovrat, Michal Caspi, Alona Zilberberg, Lital Lahav, Anastasia Firsow, Hila Gur, Rina Rosin-Arbesfeld,