کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10914655 | 1088804 | 2015 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Potent anti-tumor response by targeting B cell maturation antigen (BCMA) in a mouse model of multiple myeloma
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Potent anti-tumor response by targeting B cell maturation antigen (BCMA) in a mouse model of multiple myeloma Potent anti-tumor response by targeting B cell maturation antigen (BCMA) in a mouse model of multiple myeloma](/preview/png/10914655.png)
چکیده انگلیسی
Multiple myeloma (MM) is an aggressive incurable plasma cell malignancy with a median life expectancy of less than seven years. Antibody-based therapies have demonstrated substantial clinical benefit for patients with hematological malignancies, particular in B cell Non-Hodgkin's lymphoma. The lack of immunotherapies specifically targeting MM cells led us to develop a human-mouse chimeric antibody directed against the B cell maturation antigen (BCMA), which is almost exclusively expressed on plasma cells and multiple myeloma cells. The high affinity antibody blocks the binding of the native ligands APRIL and BAFF to BCMA. This finding is rationalized by the high resolution crystal structure of the Fab fragment in complex with the extracellular domain of BCMA. Most importantly, the antibody effectively depletes MM cells in vitro and in vivo and substantially prolongs tumor-free survival under therapeutic conditions in a xenograft mouse model. A BCMA-antibody-based therapy is therefore a promising option for the effective treatment of multiple myeloma and autoimmune diseases.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular Oncology - Volume 9, Issue 7, August 2015, Pages 1348-1358
Journal: Molecular Oncology - Volume 9, Issue 7, August 2015, Pages 1348-1358
نویسندگان
Felix Oden, Stephen F. Marino, Janko Brand, Susanne Scheu, Cathleen Kriegel, Daniel Olal, Anna Takvorian, Jörg Westermann, Buket Yilmaz, Michael Hinz, Oliver Daumke, Uta E. Höpken, Gerd Müller, Martin Lipp,