Mouse models for studying angiogenesis and lymphangiogenesis in cancer

► Tumors exploit blood and lymphatic vessels to promote their growth and metastasis. ► Targeting blood and lymphatic vasculature provides a rationale for cancer treatment. ► Most of our knowledge of the mechanisms of tumor angiogenesis is based on mouse models. ► The benefit of the thus far implemented anti-angiogenic treatments has been limited. ► The development of improved treatment requires better pre-clinical cancer models.