EGFR mediates LPA-induced proteolytic enzyme expression and ovarian cancer invasion: Inhibition by resveratrol

► LPA-induced EGFR transactivation and its inhibition for ovarian cancer progression. ► EGFR aggravates ovarian cancer progression through proteolytic enzyme secretion. ► A Gi and G13/EGFR/Ras/Rho/ROCK signaling cascade for proteolytic enzyme secretion. ► Reseveratrol inhibits EGFR activation and ovarian cancer invasion. ► Resveratrol increases the therapeutic potential of an EGFR inhibitor.