Adduct formation and repair, and translesion DNA synthesis across the adducts in human cells exposed to 3-nitrobenzanthrone

- 3-Nitrobenzanthrone formed dG-C8-N-ABA and dG-N2-C2-ABA as major adducts.
- The DNA repair system was less efficient at removing dG-N2-C2-ABA.
- dG-C8-N-ABA blocked DNA replication markedly.
- TLS across dG-C8-N-ABA resulted in a significantly increased mutation frequency.