New DNA probes to detect aneugenicity in rat bone marrow micronucleated cells by a pan-centromeric FISH analysis

- Two novel centromeric satellite sequences were identified in rat genome.
- All centromeres were detected by mixed FISH probes of rat satellite I, satellite II and satellite III.
- The method distinguished centromere-positive micronuclei from negative ones.
- Aneugenic and clastogenic modes of micronucleus induction could be discriminated.