کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10915442 | 1090060 | 2005 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Continuous Low-Dose (Metronomic) Chemotherapy on Rat Prostate Tumors Evaluated Using MRI In Vivo and Comparison with Histology
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کلمات کلیدی
AIPCDCE MRIAntiangiogenesisTHAMTDCTXAUC - AUCBOLD MRI - MRI BOLDDynamic contrast-enhanced MRI - MRI کنتراست پویاR2* - R 2 *Magnetic Resonance Imaging (MRI) - امآرآیMRI - امآرآی یا تصویرسازی تشدید مغناطیسیImmunohistochemistry - ایمونوهیستوشیمیThalidomide - تالیدومیدMagnetic resonance imaging - تصویربرداری رزونانس مغناطیسیProstate tumor - تومور پروستاتMaximum tolerated dose - حداکثر دوز قابل تحملAndrogen-independent prostate cancer - سرطان پروستات مستقل از آندروژنCyclophosphamide - سیکلوفسفامید transverse relaxation rate - نرخ آرام سازی عرضی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Continuous Low-Dose (Metronomic) Chemotherapy on Rat Prostate Tumors Evaluated Using MRI In Vivo and Comparison with Histology Continuous Low-Dose (Metronomic) Chemotherapy on Rat Prostate Tumors Evaluated Using MRI In Vivo and Comparison with Histology](/preview/png/10915442.png)
چکیده انگلیسی
Continuous low-dose (metronomic) therapy, based on cyclophosphamide (CTX) combined with thalidomide (Tha), was evaluated on Dunning prostate R3327-AT1 rat tumors. Significantly delayed tumor growth (P < .001) was observed with oral CTX alone at a low dose (metronomic cyclophosphamide or M-CTX; 30 mg/kg per day) or combined with Tha. To investigate dynamic changes in tumor physiology during early stages of treatment, magnetic resonance imaging (MRI) was applied before and during the M-CTX or M-CTX + Tha therapy. Dynamic contrast-enhanced MRI revealed significant changes in the tumor center by day 3 (P < .01); by day 7, only a thin peripheral tumor region showed high signal enhancement. There was a significant correlation between poorly enhancing fraction on day 7 and ultimate tumor growth delay (P < .02). The apparent transverse relaxation rate (R2*) showed similar baseline tumor heterogeneity, but no obvious changes with growth or therapy. Histology confirmed substantial necrosis in the tumor center, leaving a thin live peripheral rim. Immunohistochemistry showed a significant increase in vascular endothelial growth factor, apoptotic tumor and vascular endothelial cells. These results show the efficacy of the metronomic CTX ± Tha for delaying tumor growth and indicate that MRI provides insights into the mode of action and early indication of efficacy.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neoplasia - Volume 7, Issue 7, July 2005, Pages 678-687
Journal: Neoplasia - Volume 7, Issue 7, July 2005, Pages 678-687
نویسندگان
Dawen Zhao, Lan Jiang, Eric W. Hahn, Ralph P. Mason,