کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10915578 | 1090084 | 2005 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Integrin αβ3-Targeted Imaging of Lung Cancer
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کلمات کلیدی
RGDDOTAArginine-Glycine-Aspartic Acid - آرژینین-گلیسین-اسیدپارشی اسیدPositron emission tomography (PET) - توموگرافی انتشار پوزیترون (PET)Positron emission tomography - توموگرافی گسیل پوزیترونLung cancer - سرطان ریهNon small cell lung cancer - سرطان ریه سلول غیر سلولیNSCLC - سرطان ریوی غیر سلول کوچکMetastasis - متاستاز PET - پتPoly(ethylene glycol) - پلی اتیلن گلایکول PEG - پلیاتیلن گلیکول
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
A series of radiolabeled cyclic arginine-glycineaspartic acid (RGD) peptide ligands for cell adhesion molecule integrin αβ3-targeted tumor angiogenesis targeting are being developed in our laboratory. In this study, this effort continues by applying a positron emitter 64Cu-labeled PEGylated dimeric RGD peptide radiotracer 64Cu-DOTA-PEG-E[c(RGDyK)]2 for lung cancer imaging. The PEGylated RGD peptide indicated integrin αβ3 avidity, but the PEGylation reduced the receptor binding affinity of this ligand compared to the unmodified RGD dimer. The radiotracer revealed rapid blood clearance and predominant renal clearance route. The minimum nonspecific activity accumulation in normal lung tissue and heart rendered high-quality orthotopic lung cancer tumor images, enabling clear demarcation of both the primary tumor at the upper lobe of the left lung, as well as metastases in the mediastinum, contralateral lung, diaphragm. As a comparison, fluorodeoxyglucose (FDG) scans on the same mice were only able to identify the primary tumor, with the metastatic lesions masked by intense cardiac uptake and high lung background. 64Cu-DOTA-PEGE[c(RGDyK)]2 is an excellent positron emission tomography (PET) tracer for integrin-positive tumor imaging. Further studies to improve the receptor binding affinity of the tracer and subsequently to increase the magnitude of tumor uptake without comprising the favorable in vivo kinetics are currently in progress.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neoplasia - Volume 7, Issue 3, March 2005, Pages 271-279
Journal: Neoplasia - Volume 7, Issue 3, March 2005, Pages 271-279
نویسندگان
Xiaoyuan Chen, Eric Sievers, Yingping Hou, Ryan Park, Michel Tohme, Robert Bart, Ross Bremner, James R. Bading, Peter S. Conti,