99mTc-labeled gastrins of varying peptide chain length: Distinct impact of NEP/ACE-inhibition on stability and tumor uptake in mice

In situ NEP/ACE-inhibition diversely affected the in vivo profile of 99mTc-radioligands based on different-length gastrins. Truncated [99mTc]DG4 exhibited overall the most attractive profile during combined NEP/ACE-inhibition in mouse models, providing new opportunities for CCK2R-expressing tumor imaging in man with SPECT.