کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10916820 1090374 2016 19 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The spectrum of gastric pathology in portal hypertension-An endoscopic and pathologic study of 550 cases
ترجمه فارسی عنوان
طیف آسیب شناسی معده در پرفشاری خون پورتال - یک مطالعه اندوسکوپیک و پاتولوژیک 550 مورد
کلمات کلیدی
سیروز بیوپسی، گاستریت غیر هلیکوباکتر پیلوری، اکستازی عروقی انترال معده،
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
چکیده انگلیسی
One of the main tasks for pathologists when evaluating gastric biopsies from patients with portal hypertensive gastropathy (PHG) is to examine whether there is increased mucosal vasculature as suggested by endoscopy. However, the full spectrum of pathology findings in patients with portal hypertension (pHTN) is largely unknown. We systematically characterized the endoscopic and pathologic features in gastric biopsies from pHTN patients (study group) and compared with those from patients without pHTN (control group). The study group consisted of 550 consecutive surveillance esophagogastroduodenoscopic (EGD) biopsies, whereas the control group included 281 consecutive EGD biopsies for a variety of indications. As expected, the endoscopic prevalence of PHG was 28%, among which two-thirds showed corresponding histopathologic evidence of increased vasculature. However, non-Helicobacter pylori gastritis was the most common finding in pHTN patients on histology (40%). In addition, hyperplastic polyp was also more common in pHTN patients than in controls (6% vs 3%; P = 0.0314). In contrast, pathology findings of nonspecific reactive changes (29% vs 51%; P < 0.0001), proton pump inhibitor-related changes (16% vs 30%; P < 0.0001), and malignancy (1% vs 3%; P = 0.0138) were less common in pHTN patients. Our results show a spectrum of gastric endoscopic and pathologic findings in pHTN patients. The predominant gastric pathology in pHTN patients may be associated with pHTN-induced gastric microcirculation impairment.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pathology - Research and Practice - Volume 212, Issue 8, August 2016, Pages 704-709
نویسندگان
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