Black joint and synovia: Histopathological evaluation of degenerative joint disease due to Ochronosis

Histopathological diagnosis of ochronosis is not complicated given the unique “black coloring” of the affected tissues and it can easily be differentiated from other causes of detritic synovitis both clinically and histopathologically. However, there is no definitive cure for today and the reasons for late onset of arthropathy in disease course, and the mechanisms of tissue reaction to fragmented detritus remain elusive.