Long-term observations of radiation-induced creatinine clearance reduction and renal parenchymal volume atrophy

This study revealed that there was a definite relationship between DVH, renal atrophy and Ccr reduction. V20Gy < 26.6% and D30% < 19 Gy appeared to be safe dose constraints for a Ccr reduction of <20 mL/min 4 years after radiotherapy.