کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10917906 1090771 2015 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Modulation of therapeutic sensitivity by human papillomavirus
ترجمه فارسی عنوان
مدولاسیون حساسیت درمانی توسط ویروس پاپیلومای انسانی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
چکیده انگلیسی
Human papillomaviruses (HPVs) are small double-stranded DNA viruses that pose significant public health concerns as the causative agent of approximately 5% of worldwide cancers. The HPV oncogenes E6 and E7 play key roles in carcinogenesis. In the last 15 years there has been a significant increase in the incidence of HPV-related head and neck cancers arising primarily in the oropharynx. Patients with HPV-positive head and neck cancers (HNCs) have a significantly improved prognosis compared to those with HPV-negative disease. In this review we will discuss data suggesting how HPV oncogenes modulate both the intrinsic radiation sensitivity of HNCs and also have important effects upon the tumor microenvironment. Together, these findings contribute to the improved outcomes seen in patients with HPV-positive HNC.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Radiotherapy and Oncology - Volume 116, Issue 3, September 2015, Pages 342-345
نویسندگان
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