کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10918619 | 1090797 | 2014 | 16 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Second primary cancers after radiation for prostate cancer: A systematic review of the clinical data and impact of treatment technique
ترجمه فارسی عنوان
سرطان های دوم اولیه پس از تابش برای سرطان پروستات: یک بررسی سیستماتیک از داده های بالینی و تاثیر تکنیک درمان
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کلمات کلیدی
سرطان پروستات، سرطان دوم دوم، بررسی سیستماتیک،
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
چکیده انگلیسی
The development of a radiation induced second primary cancer (SPC) is one the most serious long term consequences of successful cancer treatment. This review aims to evaluate SPC in prostate cancer (PCa) patients treated with radiotherapy, and assess whether radiation technique influences SPC. A systematic review of the literature was performed to identify studies examining SPC in irradiated PCa patients. This identified 19 registry publications, 21 institutional series and 7 other studies. There is marked heterogeneity in published studies. An increased risk of radiation-induced SPC has been identified in several studies, particularly those with longer durations of follow-up. The risk of radiation-induced SPC appears small, in the range of 1 in 220 to 1 in 290 over all durations of follow-up, and may increase to 1 in 70 for patients followed up for more than 10Â years, based on studies which include patients treated with older radiation techniques (i.e. non-conformal, large field). To date there are insufficient clinical data to draw firm conclusions about the impact of more modern techniques such as IMRT and brachytherapy on SPC risk, although limited evidence is encouraging. In conclusion, despite heterogeneity between studies, an increased risk of SPC following radiation for PCa has been identified in several studies, and this risk appears to increase over time. This must be borne in mind when considering which patients to irradiate and which techniques to employ.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Radiotherapy and Oncology - Volume 110, Issue 2, February 2014, Pages 213-228
Journal: Radiotherapy and Oncology - Volume 110, Issue 2, February 2014, Pages 213-228
نویسندگان
Louise Murray, Ann Henry, Peter Hoskin, Frank-Andre Siebert, Jack Venselaar, PROBATE group of the GEC ESTRO PROBATE group of the GEC ESTRO,