Inter-application variation of dose and spatial location of D2cm3 volumes of OARs during MR image based cervix brachytherapy

The 2 cm3 volumes between the applications/fractions are quite stable in topography for bladder and rectum, and hence the current practice of cumulative addition of D2cm3 dose is expected to be valid for bladder and rectum. For sigmoid, significant topographical changes were seen, which need further validation in a larger patient population and in multi-centric settings.