Early radiation-induced mucosal changes evaluated by proctoscopy: Predictive role of dosimetric parameters

rV60 Gy, rV70 Gy and rDmean were the strongest predictors of rectal mucosal alterations. In-depth analysis is required to correlate each mucosal alteration with late rectal toxicity in order to suggest early proctoscopy as surrogate end-point for rectal late toxicity in studies aimed at reducing this important complication.