Hypoxia imaging with [18F]HX4 PET in NSCLC patients: Defining optimal imaging parameters

The majority of NSCLC lesions showed considerable [18F]HX4 uptake. The heterogeneous uptake pattern was stable between 2 h and 4 h p.i. [18F]HX4 PET imaging at 4 h p.i. is superior to 2 h p.i. to reach highest contrast. Acquisition time may be reduced to 10 min without significant effects on TBRmax and HF.