کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10924538 | 1091305 | 2005 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Cytogenetic and Molecular Genetic Abnormalities in Agnogenic Myeloid Metaplasia
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موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
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چکیده انگلیسی
Agnogenic myeloid metaplasia (AMM), a clonal hematopoietic stem cell disorder also known as chronic idiopathic myelofibrosis, is characterized by a polyclonal, or reactive, stromal proliferation, resulting from the inappropriate release of megakaryocyte/monocyte-derived growth factors. Cytogenetic studies indicate that 30% of cases possess a clonal cytogenetic abnormality at diagnosis, a figure that increases to approximately 90% following leukemic transformation. Patients with specific abnormal karyotypes have a poor prognosis and may fail to respond to androgen therapy. The incidence of chromosomal abnormalities is significantly less in younger patients, a fact that may explain their more favorable prognosis. Common findings include 13qâ, 20qâ, trisomy 8, and abnormalities of chromosomes 1, 7, and 9. However, detailed cytogenetic analysis has not yet led to the identification of pathogenetically relevant genes and, as a result, the molecular mechanisms responsible for the clonal proliferation remain unknown. Targeted gene screening has revealed only rare oncogenic point mutations in N-RAS, p53, and c-KIT.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Seminars in Oncology - Volume 32, Issue 4, August 2005, Pages 359-364
Journal: Seminars in Oncology - Volume 32, Issue 4, August 2005, Pages 359-364
نویسندگان
John T. Reilly,