Inhibition of antigen receptor-dependent Ca2+ signals and NF-AT activation by P2X7 receptors in human B lymphocytes

- Activation of the purinergic P2X7 receptor inhibits BCR-mediated [Ca2+]i responses.
- The inhibition is mediated by P2X7 receptor-dependent membrane depolarization.
- P2X7 receptor activation inhibits BCR-mediated NF-AT activation.
- P2X7 receptor activation may inhibit activation of tonsillar B lymphocytes.
- This effect may be relevant under pathophysiological extracellular ATP increase.