The two pore channel TPC2 is dispensable in pancreatic β-cells for normal Ca2+ dynamics and insulin secretion

- Mice null for Tpcn2 in pancreatic β-cells were created using LoxP-mediated deletion.
- The absence of TPC2 had no impact on intraperitoneal or oral glucose tolerance.
- Glucose and GLP-1-induced Ca2+ dynamics were unaffected in null mouse islets.
- Functional redundancy of TPC channels appears to exist in β-cells.