p11 modulates calcium handling through 5-HT4R pathway in rat ventricular cardiomyocytes

- p11 (S100A10) modulates calcium signaling in healthy cardiomyocytes.
- p11 induction positively modulates the cardiac 5-HT4R pathway.
- Cardiomyocyte p11 expression is induced by BDNF or imipramine.
- Activation of the cardiac 5-HT4R pathway is associated with diastolic Ca2+ waves.
- We highlighted a potential explanation for antidepressant cardiotoxicity.