Calcium signaling properties of a thyrotroph cell line, mouse TαT1 cells

- TαT1 thyrotrophs are excitable and generate spontaneous action potentials.
- These cells express functional calcium-mobilizing TRH and P2Y1 receptors.
- Their activation triggers rapid Ca2+ mobilization coupled to sustained Ca2 influx.
- Both store-operated and voltage-gated calcium entry contribute to sustained calcium influx.
- Cellular calcium homeostasis is affected by triiodothyronine.