Amphetamine activates calcium channels through dopamine transporter-mediated depolarization

- Amphetamine (AMPH) and dopamine (DA) induce depolarizing currents through the DA transporter (DAT).
- DAT substrate-induced depolarization activates L-type but not N-type Ca2+ channels (CaV).
- AMPH is more potent than DA when activating L-type CaV.
- The activation of L-type CaV displays higher coupling-strength with AMPH- than DA-induced currents.
- AMPH action likely involves L-type CaV activation.