Effect of M-phase kinase phosphorylations on type 1 inositol 1,4,5-trisphosphate receptor-mediated Ca2+ responses in mouse eggs

- Downregulation of IP3R1 inhibits persistent Ca2+ oscillations in mouse eggs.
- Expression of wild type IP3R1 rescues ability to mount persistent Ca2+ oscillations.
- IP3R1s with phosphomimetic mutations show higher function and oscillations.
- Exogenous IP3R1s are resistant to downregulation, which enhance oscillations.