کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10926231 | 1091787 | 2014 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Calcium dysregulation, and lithium treatment to forestall Alzheimer's disease - a merging of hypotheses
ترجمه فارسی عنوان
اختلال در تنظیم کلسیم و درمان لیتیوم برای جلوگیری از بیماری آلزایمر - ادغام فرضیات
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیولوژی سلول
چکیده انگلیسی
Intracellular Ca2+ concentrations are tightly regulated, and elevated levels sustained over periods of time can cause cellular deterioration. The putative role of dysregulated intracellular Ca2+ in Alzheimer's disease had led to the hypothesis that controlling intracellular Ca2+ may forestall cognitive decline. Lithium has been shown to reduce intracellular Ca2+ concentrations. Two well-characterized neuronal targets of lithium that may affect intracellular Ca2+ levels are N-methyl-d-aspartate (NMDA) receptors and inositol monophosphatase (IMP). Results from a recent single-center placebo-controlled randomized trial suggest that long-term lithium treatment at subtherapeutic doses may have the potential to delay the progression of disease, and observational studies have shown that lithium reduces the prevalence of dementia in subjects with bipolar disorder on long-term lithium therapy. I am advancing the hypothesis that lithium may protect against cognitive decline by stabilizing intracellular Ca2+ through a dual, synergistic mechanism of targeting both extracellular and intracellular sites, via antagonizing NMDA-receptors and inhibiting IMP. Insights derived from this hypothesis could lead to an improved understanding of the molecular pathology of Alzheimer's disease, and have implications on the evaluation and use of therapeutics that alter intracellular Ca2+ levels.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cell Calcium - Volume 55, Issue 3, March 2014, Pages 175-181
Journal: Cell Calcium - Volume 55, Issue 3, March 2014, Pages 175-181
نویسندگان
James Wallace,