TRPV4 channels activity in bovine articular chondrocytes: Regulation by obesity-associated mediators

- A hypotonic challenge activates a cation current carried by TRPV4 channels.
- TRPV4 currents can depolarize the cell.
- TRPV4 currents can explain hypotonicity-induced [Ca2+]i increase.
- TRPV4 channels are regulated by some obesity-altered agents.
- TRPV4 regulation may help to understand the link between OA and obesity.