Store-operated Ca2+ entry and depolarization explain the anomalous behaviour of myometrial SR: Effects of SERCA inhibition on electrical activity, Ca2+ and force

- SERCA pump inhibition by CPA caused membrane depolarization, activation of action potentials, Ca2+ spikes and force.
- Depletion of Ca2+ store by agonists leads to membrane depolarization and activation of electrical and mechanical activity.
- Ca2+ release/Ca2+ entry coupling is playing a key role in control of spontaneous electrical and mechanical activity in rat pregnant myometrium.