کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10926995 | 1092292 | 2015 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Functions of thymic stromal lymphopoietin in non-allergic diseases
ترجمه فارسی عنوان
تومورهای لنفوپویتین استروما اگزوس در بیماری های غیر آلرژیک
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیولوژی سلول
چکیده انگلیسی
Thymic stromal lymphopoietin (TSLP) is an interleukin 7-like cytokine produced mainly by epithelial cells. Many studies indicate that TSLP contributes to promote T helper (Th) 2 immune responses which are associated with the pathogenesis of allergic inflammatory diseases. Base on the cross-talk between Th2 inflammation and cancers, we will highlight the role of TSLP in the progression of cancers in this review. TSLP is involved in the increasing prevalence of Tregs in the cancer microenvironment. Besides, TSLP has an important role in promoting the growth of vascular endothelial cells and angiogenesis, which could further promote the development and progression of cervical cancer. It gives the evidence that TSLP could induce EMT to promote cancer metastasis. In addition, TSLP could be detected in some fibroblasts and may play a role in the pathogenesis of non-allergic diseases characterized by a type 2 immune response and organ fibrosis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cellular Immunology - Volume 295, Issue 2, June 2015, Pages 144-149
Journal: Cellular Immunology - Volume 295, Issue 2, June 2015, Pages 144-149
نویسندگان
Guoqing Ying, Yanlu Zhang, Guoqiang Tang, Shuqing Chen,