کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10927003 | 1092296 | 2015 | 34 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Iopromide in combination with IFN-γ induces the activation of HMC-1 cells via IL-4 and MCP-1 expression
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موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیولوژی سلول
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![عکس صفحه اول مقاله: Iopromide in combination with IFN-γ induces the activation of HMC-1 cells via IL-4 and MCP-1 expression Iopromide in combination with IFN-γ induces the activation of HMC-1 cells via IL-4 and MCP-1 expression](/preview/png/10927003.png)
چکیده انگلیسی
In this study, we investigated whether IFN-γ has a role in contrast-medium-induced adverse reactions. Iopromide, a nonionic iodinated contrast agent, slightly induced mast cell proliferation and significantly increased the expression of IL-4 and MCP-1 at low doses. The pretreatment of cells with IFN-γ dramatically increased the expression of iopromide-induced IL-4 and MCP-1. An evaluation of mast cell activator secretion revealed that IFN-γ- or IL-4-pretreated HMC-1 cells released dramatically increased levels of β-hexosaminidase and histamine when stimulated with iopromide. We also found that the migration of EoL-1 and THP-1 cells was significantly increased in culture conditions with iopromide-stimulated IL-4-pretreated HMC-1 cells. Taken together, our findings suggest that measuring IFN-γ or IL-4 levels in serum would be helpful as a potential biomarker of adverse patient reactions and that blocking IFN-γ or IL-4 may be crucial in preventing the delayed allergy-like reaction induced by contrast medium in patients with various diseases.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cellular Immunology - Volume 293, Issue 2, February 2015, Pages 95-103
Journal: Cellular Immunology - Volume 293, Issue 2, February 2015, Pages 95-103
نویسندگان
Hae-Yun Cho, Seok Jin Choi, Soo-Woon Lee, Yang Weon Kim, Chae Kwan Lee, Soo-Woong Lee,