Context and location dependence of adaptive Foxp3+ regulatory T cell formation during immunopathological conditions

- iTreg and nTreg are non-redundant, and have distinct roles and antigen specificity.
- iTreg are important for the induction of gastrointestinal tolerance.
- iTreg formation is inconsistent in models of autoimmune or neoplastic disease.
- The role of iTreg in immunopatholgic conditions is context and location dependent.