Characterization of fibrosis-promoting factors and siRNA-mediated therapies in C-protein-induced experimental autoimmune myocarditis

- Experimental carditis was induced and fibrosis-related molecules were examined.
- Only transforming growth factor-β1 (TGF-β1)-positive cells were present by 8 weeks.
- siRNA for MMP-2 and -9 reduced the severities of inflammation and fibrosis.