The hybrid between the ABC domains of synapsin and the B subunit of Escherichia coli heat-labile toxin ameliorates experimental autoimmune encephalomyelitis

► Synapsin ABC-peptide fused to Escherichia coli labile toxin B subunit decreases EAE severity. ► Tolerance with fusion protein LTBABC increases Th3 cytokine secretion. ► EAE modulation by the hybrid LTBABC induces expansion of regulatory T cells.