Over-expressing transporters associated with antigen processing increases antitumor immunity response in prostate cancer

► APM expression was down-regulated in prostae cancer by immunohistochemistry. ► PC-3 cells pretreated with TAP1 lentivirus can restore the APM expression. ► In vitro, PC-3 cells infected with Lenti-TAP1 induce apoptosis and activate T cells. ► In vivo, the Lenti-TAP1 treatment increases survival and immune cells infiltration.