کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10927161 1092396 2005 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The role of Rac1 and Rac2 in bacterial killing
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
The role of Rac1 and Rac2 in bacterial killing
چکیده انگلیسی
The small Rho guanosine triphosphatases (GTPases) Rac1 and Rac2 have distinct roles in regulating neutrophil chemotaxis; however, little is known about their possible unique roles in mediating bacterial killing. To elucidate the relative roles of Rac1 and Rac2 in regulating neutrophil-mediated bacterial killing, we utilized the previously described mice model in which mouse neutrophils are deficient in either Rac1, Rac2, or both isoforms. We demonstrate here that while both Rac isoforms are required for normal neutrophil chemotaxis and bacterial killing, they have non-overlapping roles in bacterial phagocytosis and NADPH oxidase function.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cellular Immunology - Volume 235, Issue 2, June 2005, Pages 92-97
نویسندگان
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