کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10928097 | 1092896 | 2013 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Investigating the cryoablative efficacy of a hybrid cryoprobe operating under freeze-thaw cycles
ترجمه فارسی عنوان
بررسی اثر فیزیولوژیکی گریوپروب ترکیبی تحت چرخه یخ زدایی
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
علوم کشاورزی و بیولوژیک (عمومی)
چکیده انگلیسی
Cryoprobes are minimally invasive tools that apply extremely low temperatures to eradicate undesirable cancerous tissue during cryosurgery. At times, they may generate thermal injury to neighboring good tissue leading to the case of over-ablation. The magnitude of this problem becomes significant when tumors are complex, large size and irregular in shape. In this work, we propose a simple yet pragmatic hybrid cryoprobe which can potentially promote better surgical efficacy by improving tumor ablation while reducing undesired thermal injury to the neighboring tissue. To evaluate the performance of the proposed probe operating under cyclic freeze-thaw conditions, a detailed bioheat transfer model incorporating tissue death functions was developed. In-vitro experiments conducted to validate the model yielded a good agreement of 6.7%. We numerically studied the thermal impact of employing the hybrid cryoprobe on tissue temperature distributions. Evaluating the hybrid cryoprobe's control ability, we showed that the proposed device was able to regulate the growth of the ice front while sustaining an excellent coverage of the ablation zone. We also noted the existence of a diminishing temperature effect when alternate freeze-thaw cycles were applied. The performance of the hybrid cryoprobe could potentially lead to a portable and cost-effective device that may prove hugely beneficial for the purposes of surgical planning, rehearsal and control.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cryobiology - Volume 66, Issue 3, June 2013, Pages 239-249
Journal: Cryobiology - Volume 66, Issue 3, June 2013, Pages 239-249
نویسندگان
X. Zhao, K.J. Chua,