Plasma membrane growth during the cell cycle: unsolved mysteries and recent progress

► Growth of the plasma membrane during the cell cycle is essential for cell reproduction. ► Initiation, location, and extent of membrane growth must be precisely controlled. ► Recent experiments have linked membrane growth to core cell cycle regulators. ► Analysis of these links will yield insights into fundamental mechanisms of cell growth. ► Understanding post-Golgi pathways of membrane growth will be essential for future progress.